The synaptic tagging hypothesis attempts to solve the difficult problem of the cell, to synthesize proteins in the cell body, but to ensure that they only reach synapses that have received LTP industant stimuli. After consulting the publishing house, this book is accessible via the search function, but cannot be searched. These comments are attached to the LTP and forwarded at the same time as the LTP to the Beamtime Allocation Committees for review. NMDA receptor-dependent LTP has several characteristics, including initial specificity, associativity, coopativity, and persistence. In a 2003 review, Rowan et al. proposed a model on how LTP might be influenced at AD. [62] DPA appears to be due, at least in part, to poor transformation of the amyloid precursor protein (APP). The result of this abnormal transformation is the accumulation of fragments of this protein, called amyloid β (Ab). .